Compromise Solutions for Bankruptcy Situations with References

This paper deals with bankruptcy situations in which in addition to the claims, an exogenously given reference point for the allocation of the estate is present.We introduce and analyse two types of compromise solutions and show that they coincide with the T value of two corresponding TU games.We apply our solutions to a real-life case of allocating university money to degree courses.bankruptcy;allocation;t-value;games

Diseño, síntesis y evaluación citotóxica de un inhibidor selectivo de la recaptación de serotonina (ISRS) mediante cribado virtual

La depresión es una de las enfermedades mentales más comunes y afecta a casi 300 millones de personas. Según la OMS, la depresión es una de las principales causas de discapacidad y morbilidad en el mundo. Las personas que padecen esta enfermedad requieren tratamiento tanto psicológico como farmacológico, ya que los episodios depresivos graves suelen desembocar en suicidio. Los inhibidores selectivos de la recaptación de serotonina (ISRS) son antidepresivos muy utilizados que actúan sobre el transportador humano de serotonina (hSERT). La cristalización del hSERT y los datos experimentales disponibles permiten utilizar herramientas computacionales de coste y tiempo eficientes, como el cribado virtual (VS), en el desarrollo de agentes terapéuticos. En este trabajo sintetizamos, caracterizamos y evaluamos la actividad biológica de un nuevo análogo ISRS de la paroxetina, diseñado racionalmente mediante la aplicación de un modelo QSAR basado en redes neuronales artificiales y un análisis de acoplamiento molecular sobre hSERT. El análogo N-sustituido 18a mostró mayor afinidad por el transportador (-10,2 kcal/mol), menor valor Ki (1,19 nM) y un perfil toxicológico más seguro que la paroxetina y se sintetizó con un rendimiento del 71%. La citotoxicidad in vitro del análogo se evaluó utilizando líneas celulares de glioblastoma humano (U87 MG), neuroblastoma humano (SH SY5Y) y fibroblastos murinos (L929). También se evaluó la capacidad hemolítica del compuesto en eritrocitos humanos. Los resultados mostraron que el análogo 18a no mostró actividad citotóxica en las líneas celulares utilizadas y no tiene actividad hemolítica en ninguna de las concentraciones ensayadas, mientras que con paroxetina se observó hemólisis a 2,3, 1,29 y 0,67 mM. En base a estos resultados, es posible sugerir que el análogo 18a podría ser un nuevo y prometedor candidato a ISRS para el tratamiento de esta enfermedad.Depression is one of the most common mental illnesses, affecting almost 300 million people. According to the WHO, depression is one of the world's leading causes of disability and morbidity. People with this illness require both psychological and pharmaceutical treatment because severe depressive episodes often result in suicide. Selective serotonin reuptake inhibitors (SSRI) are widely used antidepressants that target the human serotonin transporter (hSERT). The crystallization of hSERT and the experimental data available allows cost and time-efficient computational tools like virtual screening (VS) to be utilized in the development of therapeutic agents. Here, we synthesized, characterized, and evaluated the biological activity of a novel SSRI analog of paroxetine, rationally designed by applying an artificial neural network-based QSAR model and a molecular docking analysis on hSERT. The analog N-substituted 18a showed higher affinity for the transporter (-10.2 kcal/mol), lower Ki value (1.19 nM) and a safer toxicological profile than paroxetine and was synthesized with a 71% yield. The in vitro cytotoxicity of the analog was evaluated using human glioblastoma (U87 MG), human neuroblastoma (SH SY5Y) and murine fibroblast (L929) cell lines. Also, the hemolytic ability of the compound was assessed on human erythrocytes. Results showed that analog 18a did not exhibit cytotoxic activity on the cell lines used and has no hemolytic activity at any of the concentrations tested, whereas with paroxetine, hemolysis was observed at 2.3, 1.29 y 0.67 mM. Based on these results, it is possible to suggest that analog 18a could be a promising new SSRI candidate for the treatment of this illness

Predictions from non trivial Quark-Lepton complementarity

The complementarity between the quark and lepton mixing matrices is shown to provide robust predictions. We obtain these predictions by first showing that the matrix V_M, product of the quark (CKM) and lepton (PMNS) mixing matrices, may have a zero (1,3) entry which is favored by experimental data. We obtain that any theoretical model with a vanishing (1,3) entry of V_M that is in agreement with quark data, solar, and atmospheric mixing angle leads to $\theta_{13}^{PMNS}=(9{^{+1}_{-2}})^\circ$. This value is consistent with the present 90% CL experimental upper limit. We also investigate the prediction on the lepton phases. We show that the actual evidence, under the only assumption that the correlation matrix V_M product of CKM and PMNS has a zero in the entry (1,3), gives us a prediction for the three CP-violating invariants J, S_1, and S_2. A better determination of the lepton mixing angles will give stronger prediction for the CP-violating invariants in the lepton sector. These will be tested in the next generation experiments. Finally we compute the effect of non diagonal neutrino mass in "l_i -> l_j gamma" in SUSY theories with non trivial Quark-Lepton complementarity and a flavor symmetry. The Quark-Lepton complementarity and the flavor symmetry strongly constrain the theory and we obtain a clear prediction for the contribution to "mu -> e gamma" and the "tau" decays "tau -> e gamma" and "tau -> mu gamma". If the Dirac neutrino Yukawa couplings are degenerate but the low energy neutrino masses are not degenerate, then the lepton decays are related among them by the V_M entries. On the other hand, if the Dirac neutrino Yukawa couplings are hierarchical or the low energy neutrino masses are degenerate, then the prediction for the lepton decays comes from the CKM hierarchy.Comment: 15 pages, 5 figures, ws-ijmpa class included, Proceedings of the CTP Symposium on Sypersymmetry at LH

A DEA Approach for Evaluating the Labor Efficiency in the Rural Hotel Industry: A Case Study in Spain

In this paper, labor efficiency in the rural hotel industry is analyzed while considering the characteristics regarding labor and infrastructure of the various Spanish provinces. The methodological procedure consisted of the analysis of 52 Spanish provinces. As analysis, Data Envelopment Analysis (DEA) and Multivariate Analysis have been used. Although rural tourism is consolidated in the Spanish holiday culture, the effect of labor efficiency on Spanish provinces is uneven. Performance depends on the geographical area; thus, labor efficiency is only achieved in Asturias and Balearic Islands, where rural tourism has a strong and positive impact on employment. The variable length of stay of the holiday period carries important weight for labor efficiency to be reached in said provinces. It can be observed that hotels located in places with charm and with special environmental protection contribute directly to the labor efficiency of the area due to the direct relationship between the area of protected land and the labor efficiency of the province. Several provincial groups are established with a variety of different characteristics, which confirms that the level of labor efficiency in the sector has yet to be maximized

Possible Tomography of the Sun's Magnetic Field with Solar Neutrinos

The data from solar neutrino experiments together with standard solar model predictions are used in order to derive the possible profile of the magnetic field inside the Sun, assuming the existence of a sizeable neutrino magnetic moment and the resonant spin flavour mechanism. The procedure is based on the relationship between resonance location and the energy dependent neutrino suppression, so that a large neutrino suppression at a given energy is taken to be connected to a large magnetic field in a given region of the Sun. In this way it is found that the solar field must undergo a very sharp increase by a factor of at least 6 - 7 over a distance no longer than 7 - 10% of the solar radius, decreasing gradually towards the surface. The range in which this sharp increase occurs is likely to be the bottom of the convective zone. There are also indications in favour of the downward slope being stronger at the start and more moderate on approaching the solar surface. Typical ranges for the magnetic moment are from a few times 10^{-13}\mu_B to its laboratory upper bounds while the mass square difference between neutrino flavours is of order (0.6-1.9) x 10^{-8}eV^2.Comment: Several minor corrections performed, sunspot anticorrelation discussed, references added, 29 pages including 8 figures in PostScrip

The nuclear and extended mid-infrared emission of Seyfert galaxies

We present subarcsecond resolution mid-infrared (MIR) images obtained with 8-10 m-class ground-based telescopes of a complete volume-limited (DL<40 Mpc) sample of 24 Seyfert galaxies selected from the Swift/BAT nine month catalog. We use those MIR images to study the nuclear and circumnuclear emission of the galaxies. Using different methods to classify the MIR morphologies on scales of ~400 pc, we find that the majority of the galaxies (75-83%) are extended or possibly extended and 17-25% are point-like. This extended emission is compact and it has low surface brightness compared with the nuclear emission, and it represents, on average, ~30% of the total MIR emission of the galaxies in the sample. We find that the galaxies whose circumnuclear MIR emission is dominated by star formation show more extended emission (650+-700 pc) than AGN-dominated systems (300+-100 pc). In general, the galaxies with point-like MIR morphologies are face-on or moderately inclined (b/a~0.4-1.0), and we do not find significant differences between the morphologies of Sy1 and Sy2. We used the nuclear and circumnuclear fluxes to investigate their correlation with different AGN and SF activity indicators. We find that the nuclear MIR emission (the inner ~70 pc) is strongly correlated with the X-ray emission (the harder the X-rays the better the correlation) and with the [O IV] lambda 25.89 micron emission line, indicating that it is AGN-dominated. We find the same results, although with more scatter, for the circumnuclear emission, which indicates that the AGN dominates the MIR emission in the inner ~400 pc of the galaxies, with some contribution from star formation.Comment: 27 pages, 12 figures, accepted by MNRA